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Podofilox is sometimes marketed under the brand name Condylox. Podofilox solution is made from several types of plant families. Podofilox solution is meant to be used topically and is typically available in a podofilox 5 mg / mL solution. The podofilox dosage and regimen used sometimes varies from patient to patient, depending on the specific health needs and the judgment of the prescribing medical provider. Costs associated with podofilox cream, solution or gel medication vary from person to person and people paying out of pocket may be able to find podofilox coupons online or through other sources. Additionally, some insurance plans may help cover costs associated with a podofilox cream prescription. It is recommended to consult the package insert that comes with the podofilox solution to learn about what storage conditions are recommended for the medication.
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One cannot just buy podofilox online or get podofilox OTC in the United States from a pharmacy as it is a medication that requires a prescription before it can be dispensed. Because of this restriction, the first step to getting a podofilox cream prescription is consulting a licensed medical provider. People who might need a podofilox prescription, however, can use Push Health to connect with a local medical provider who can prescribe podofilox solution, gel or cream when appropriate to do so.
Like most medications, podofilox prescription medication can cause side effects when used. Prior to using podofilox, it is important to discuss possible side effects and other concerns with a qualified medical provider. People with a known hypersensitivity to podofilox or ingredients in the formulation should not use podofilox medication.
Many medicines have not been studied specifically in older people. Therefore, it may not be known whether they work exactly the same way they do in younger adults or if they cause different side effects or problems in older people. There is no specific information comparing use of podofilox in the elderly with use in other age groups.
A paper with information for the patient will be given to you with your filled prescription and will provide many details concerning the use of podofilox. Read this paper carefully and ask your health care professional if you need additional information.
Also, keep podofilox away from the eyes and mucous membranes, such as the inside of the penis, rectum, or vagina. This medicine may cause severe irritation. If you get this medicine in your eyes or on one of these areas, immediately flush the area with water for 15 minutes.
Use podofilox only as directed, no more than 3 days a week and no more than 4 treatment cycles. Do not use more of it, do not use it more often, and do not use it for a longer time than your doctor ordered. To do so may increase the chances that this medicine is absorbed into the body and that side effects could occur.
Do not apply the medicine to any other wart until you discuss it with your doctor. The total dose of podofilox used on all warts should not exceed that which would cover an area measuring 1.6 square inches (10 square centimeters), about the size of a dollar coin.
Genital warts caused by human papillomavirus infection are encountered commonly in primary care. Evidence guiding treatment selection is limited, but treatment guidelines recently have changed. Biopsy, viral typing, acetowhite staining, and other diagnostic measures are not routinely required. The goal of treatment is clearance of visible warts; some evidence exists that treatment reduces infectivity, but there is no evidence that treatment reduces the incidence of cervical and genital cancer. The choice of therapy is based on the number, size, site, and morphology of lesions, as well as patient preferences, cost, convenience, adverse effects, and clinician experience. Patient-applied therapy such as imiquimod cream or podofilox is increasingly recommended. Podofilox, imiquimod, surgical excision, and cryotherapy are the most convenient and effective options. Fluorouracil and interferon are no longer recommended for routine use. The cost per successful treatment course is approximately $200 to $300 for podofilox, cryotherapy, electrodesiccation, surgical excision, laser treatment, and the loop electrosurgical excision procedure.
Podofilox is a 0.5 percent gel or solution containing purified extract of the most active compound of podophyllin. To prevent local irritation, patients should allow the solution to dry before moving around. The solution should be applied with a cotton swab; gel should be applied with a finger. Some physicians prefer to perform the initial application. Podofilox is not recommended for treatment of perianal, rectal, urethral, or vaginal lesions. Five randomized trials comparing podofilox with podophyllin found no difference in wart clearance rates.8
A recent cost-effectiveness analysis10 found that treatment for simple genital warts costs approximately $200 to $300 for one course of podofilox, cryotherapy, electrodesiccation, surgical excision, LEEP, or laser treatment. Podophyllin resin, TCA, and imiquimod treatment were more expensive, and interferon treatment was much more expensive. For extensive condyloma that requires prolonged treatment, podofilox remains the least expensive patient-applied treatment. Surgical excision, LEEP, and electrodesiccation also were inexpensive, while cryotherapy and podophyllin resin treatments were somewhat more expensive. Interferon treatment remained the most expensive alternative.
Podophyllin, podofilox, and fluorouracil should not be used in pregnant patients because of possible teratogenicity. Imiquimod is not approved for use in pregnant women, although treatment with this agent can be considered after informed consent has been obtained.14 TCA has been used in pregnant patients without adverse effects. Surgical excision, cryotherapy, and electrocautery are appropriate treatment options during pregnancy if treatment is necessary. Some guidelines indicate that cryotherapy is safe if only three to four treatments are given, based on an older case series of 34 pregnant women demonstrating the safety of some cryotherapy treatments.16 The goal of treatment in pregnant women primarily is to minimize neonatal exposure to the virus by reducing the number of lesions present during delivery. Anogenital warts and laryngeal papillomatosis are potential complications in infected children.
Before using podofilox, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.
Podofilox (podophyllotoxin) is a patient-applied antimitotic drug that causes wart necrosis. Podofilox solution (using a cotton swab) or podofilox gel (using a finger) should be applied to anogenital warts 2 times/day for 3 days, followed by 4 days of no therapy. This cycle can be repeated, as necessary, for up to four cycles. The total wart area treated should not exceed 10 cm2, and the total volume of podofilox should be limited to 0.5 mL/day. If possible, the health care provider should apply the initial treatment to demonstrate proper application technique and identify which warts should be treated. Mild to moderate pain or local irritation might develop after treatment. After each treatment, the gel or solution should be allowed to dry. Patients should wash their hands before and after each application. Podofilox is contraindicated during pregnancy (431). 041b061a72